Shaker and Shal Mediate Transient Calcium-Independent Potassium Current in a Drosophila Flight Motoneuron

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Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron.

Ionic currents underlie the firing patterns, excitability, and synaptic integration of neurons. Despite complete sequence information in multiple species, our knowledge about ion channel function in central neurons remains incomplete. This study analyzes the potassium currents of an identified Drosophila flight motoneuron, MN5, in situ. MN5 exhibits four different potassium currents, two fast-a...

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Firing properties of neurons are important in signal detection and generation in nervous system. Spinal cord motoneurons have membrane properties adapted to muscle properties. In this work we explored the relation between the first interspike interval and the amplitude of injected current. It was shown that increased sensitivity of firing frequency to the injected current at higher firing frequ...

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A Drosophila mutation that eliminates a calcium-dependent potassium current.

A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2009

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00693.2009